解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The present study explores the potential of nanoemulsion, a lipid drug delivery system, to improve solubility and oral absorption of Silybum marianum extract. The optimized formulation contained 40 mg/mL of commercial extract (4 % w/w) and it was composed of 2.5 g labrasol (20 %) as the oil phase, 1.5 g cremophor EL a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-110052
更新日期:2017-10-01 00:00:00
abstract::Epilobium sp. are commonly used in traditional medicine in the treatment of early stages of benign prostatic hyperplasia and inflammation. It is suggested that a dominating constituent, oenothein B, is responsible for the extracts therapeutic effects. Several bioactivities were established for extracts and oenothein B...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-109372
更新日期:2017-10-01 00:00:00
abstract::DNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these m...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0043-113448
更新日期:2017-10-01 00:00:00
abstract::Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-124493
更新日期:2017-08-01 00:00:00
abstract::In this study the first supercritical fluid based protocol for the extraction, analysis, and isolation of six polar compounds, i.e., o-vanillin (1), styracin (2), vanillin (3), trans-cinnamic acid (4), vanillic acid (5), and shikimic acid (6), was developed. First, eight styrax resin products (R1-R8) obtained from var...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-105499
更新日期:2017-08-01 00:00:00
abstract::Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting m...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-108122
更新日期:2017-08-01 00:00:00
abstract::Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted t...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0043-104933
更新日期:2017-05-01 00:00:00
abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-122344
更新日期:2017-05-01 00:00:00
abstract::Herpes simplex virus infections persist throughout the lifetime of the host and affect more than 80 % of the humans worldwide. The intensive use of available therapeutic drugs has led to undesirable effects, such as drug-resistant strains, prompting the search for new antiherpetic agents. Although diverse bioactivitie...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-117774
更新日期:2017-04-01 00:00:00
abstract::Protopanaxatriol and protopanaxadiol exhibit limited oral bioavailability due to the poor solubility and intestinal cytochromes P450-mediated metabolism. This study set out to develop a novel cytochromes P450 inhibitory excipient(s)-based self-microemulsion to encapsulate protopanaxatriol and protopanaxadiol so as to ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106726
更新日期:2017-03-01 00:00:00
abstract::Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-100017
更新日期:2017-03-01 00:00:00
abstract::In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chem...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-116324
更新日期:2017-02-01 00:00:00
abstract::Five new triterpenoid saponins (1-5) and four known triterpenoid saponins, ginsenoside Re5 (6), majonoside R1 (7), 24(R)-majonoside R1 (8), and ginsenoside Rf (9), were isolated from the rhizomes of Panacis majoris. The structures of new compounds were elucidated as (20S,24S,25R*)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-g...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-117554
更新日期:2017-02-01 00:00:00
abstract::Arctigenin is a phenylpropanoid dibenzylbutyrolactone lignan compound possessing antitumor, anti-inflammatory, anti-influenza, antioxidant, antibacterial, and hypoglycaemic activities. Our previous study demonstrated that arctigenin exerts neuroprotective effects both in vitro and in vivo in a Parkinson's disease mode...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-107471
更新日期:2017-01-01 00:00:00
abstract::Silybum marianum Gaertn. (Milk thistle) has been used since ancient times for the relief of liver diseases characterized by intense oxidative stress such as inflammatory liver disease and cirrhosis. As oxidative stress by hyperglycemia is involved in micro- and macrovascular complications of type 2 diabetes, our aim w...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-113135
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to observe the protective effects of α-boswellic acids on hypoxia-induced pulmonary vascular structural remodeling in pulmonary arterial smooth muscle cells in a hypertensive rat model. Pulmonary arterial smooth muscle cells were cultured and then randomly divided into four groups: normox...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-109069
更新日期:2017-01-01 00:00:00
abstract::Phytochemical investigation of the ethyl acetate extract from the aerial parts of Eryngium triquetrum Vahl resulted in the isolation of new polyacetylenes, triquetridiol (6) and trans-epoxy-triquetrol (7a/7b, diastereomeric mixture), and the lignan demethoxy carolignan Z (8a/8b, erythro/threo pair), together with a se...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-110316
更新日期:2016-11-01 00:00:00
abstract::Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously, we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be accounted for by...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-108590
更新日期:2016-09-01 00:00:00
abstract::Tryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, 5-LOX catalyzed leukotriene synthesis, and mast cell degranulation at low µM to nM concentrations. To ass...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-110323
更新日期:2016-08-01 00:00:00
abstract::YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106170
更新日期:2016-08-01 00:00:00
abstract::Herbal medicine has been used to treat diseases for centuries; however, the biological active components and the mechanistic understanding of actions of plant-derived drugs are permanently discussed. MicroRNAs are a class of small, non-coding RNAs that play crucial roles as regulators of gene expression. In recent yea...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0042-108450
更新日期:2016-08-01 00:00:00
abstract::Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associate...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-103245
更新日期:2016-06-01 00:00:00
abstract::Transient receptor potential channels and cannabinoid receptors are deputed to the regulation of sensory, homeostatic, and inflammatory events in the human organism. Therefore, their modulation promises to have relevant applications in important therapeutic areas such as inflammation, pain, and cancer. This review sum...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0042-101352
更新日期:2016-06-01 00:00:00
abstract::Antarctic benthic communities are regulated by abundant interactions of different types among organisms, such as predation, competition, etc. Predators are usually sea stars, with omnivorous habits, as well as other invertebrates. Against this strong predation pressure, many organisms have developed all sorts of defen...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0042-105652
更新日期:2016-06-01 00:00:00
abstract::Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106168
更新日期:2016-06-01 00:00:00
abstract::Ganoderma is a genus of medicinal mushroom traditionally used for treating various diseases. Ganoderic acid A is one of the major bioactive Ganoderma triterpenoids isolated from Ganoderma species. Herein, we produced a highly specific monoclonal antibody against ganoderic acid A (MAb 12 A) and developed an indirect co...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-104202
更新日期:2016-05-01 00:00:00
abstract::Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable cancer-preventing components from red ginseng and it has been reported that ginsenoside Rh2 exhibited potent cytotoxicity against human hepat...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101764
更新日期:2016-05-01 00:00:00
abstract::Rice bran, a by-product of brown rice milling, is a rich source of dietary fiber and protein, and its usage as a functional food is expected to increase. In this study, immunomodulatory effects of glycoprotein obtained from rice bran were studied in normal mice and mouse models of cyclophosphamide-induced immunosuppre...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101944
更新日期:2016-05-01 00:00:00
abstract::Amyloid-β, one of the hallmarks of Alzheimer's disease, is toxic to neurons and causes cell death in the brain. Oxidative stress is known to play an important role in Alzheimer's disease, and there is strong evidence linking oxidative stress to amyloid-β. The herbal plant "Tiew kon" (Cratoxylum formosum ssp. pruniflor...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0041-111621
更新日期:2016-04-01 00:00:00
abstract::The leaves of Echinodorus grandiflorus are traditionally used in Brazil to treat several inflammatory conditions, including arthritis. This study aimed to investigate the antiarthritis activity of the 70% ethanol extract of E. grandiflorus leaves and a standardized flavonoid-rich fraction in an antigen-induced arthrit...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1568200
更新日期:2016-03-01 00:00:00
abstract::At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101247
更新日期:2016-03-01 00:00:00
abstract::Angelicae Sinensis Radix is commonly used in traditional Chinese medicine. Pharmacological studies show that Angelicae Sinensis Radix has clear anticoagulant activity. Therefore, in this study, the anticoagulant activity of crude Angelicae Sinensis Radix extracts was investigated by measuring the thrombin times of the...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558309
更新日期:2016-03-01 00:00:00
abstract::Acute kidney injury is a common and severe complication of acute myocardial infarction and cardiac surgery. It results in increased mortality, morbidity, and duration of hospitalization. Baicalein is a component of the root of Scutellaria baicalensis, which has traditionally been used to treat cardiovascular and liver...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558114
更新日期:2016-02-01 00:00:00
abstract::Many herbs, and recently their biomass from in vitro cultures, are essential for the treatment of diseases. The aim of this study was to determine the optimal growth of Bacopa monnieri (water hyssop) in an in vitro culture and to examine if extracts of the B. monnieri biomass from the in vitro culture would affect hyd...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558166
更新日期:2016-02-01 00:00:00
abstract::Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevan...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1557902
更新日期:2016-01-01 00:00:00
abstract::Agnus Castus Fruit is defined in the European Pharmacopoeia as the dried ripe fruit of Vitex agnus-castus. In Europe it is used as a medicine targeting premenstrual syndrome and climacteric disorder. In Japan, Agnus Castus Fruit is becoming popular as a raw material for over-the-counter drugs and health food products,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558089
更新日期:2016-01-01 00:00:00
abstract::Andrographis paniculata contains four major active diterpenoids, including andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4), which exhibit differences in types and/or degrees of their pharmacological activity. Previous pharmacokinetic studies in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558115
更新日期:2016-01-01 00:00:00
abstract::Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1546116
更新日期:2015-11-01 00:00:00
abstract::In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545912
更新日期:2015-11-01 00:00:00
abstract::We previously reported that total coumarins, the major active components of Urtica dentata Hand, exhibited substantial protection against the development of autoimmune diabetes. Diabetic nephropathy is one of the most serious complications of diabetes and is closely correlated with end-stage renal disease. We used the...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1557866
更新日期:2015-10-01 00:00:00